FIGURE 6.

HIRA disruption mainly affects stress-responsive gene expression. A–C, fold change of gene expression under priming stress (40 °C for 1 h) condition compared with no stress condition is plotted for wild-type (JK317), slm9Δ (MC3749), and hip1Δ (MC3725) cells. Horizontal bars represent the means of fold change, and mean values are shown below the abscissa axis. Fold change in expression of all genes (A), CESR genes (B), and genes whose expression was increased more than 2-fold in wild-type cells (C) is shown. Significant difference in expression between wild-type and mutant cells was determined by Student's t test (*, p < 0.05; **, p < 0.01).