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LPS up-regulates TNF-α and RANKL mRNA expression mainly through NFκB pathway. ST2 cells were pretreated with dicumarol, SB202190, CAPE, or medium and treated with medium or LPS for 2 or 12 h. TNF-α and RANKL mRNA expression were analyzed 2 h and 12 h after LPS stimulation, respectively. Dicumarol is a JNK MAPK inhibitor, SB202190 is a p38 MAPK inhibitor, and CAPE is an NFκB inhibitor. **, p < 0.01.
