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. 2012 May 23;287(28):23537–23548. doi: 10.1074/jbc.M112.363960

FIGURE 3.

FIGURE 3.

MSDC-0602 treatment improves whole body and tissue insulin sensitivity in DIO mice. Hyperinsulinemic clamp studies performed after 3 weeks of treatment with MSDC-0602 in DIO mice demonstrate a significant improvement in plasma insulin concentration (A), glucose infusion rate (B), tissue glucose uptake (C), and hepatic glucose production (D). n = 11 per group. *, p < 0.05 versus DIO control diet mice. **, p < 0.05 versus clamped DIO control mice and basal values for MSDC-0602-treated mice. AUC, area under the curve. E, representative Western blots using liver lysates from mice injected with insulin (I) before sacrifice and the antibodies listed at the left are shown. The table inset represents the normalized and corrected (to total Akt) band intensity for insulin-stimulated Akt phosphorylation for n = 3 per group. Expression of the indicated genes in liver is depicted in the graphs. n = 8 per group. *, p < 0.05 versus lean and MSDC-0602-treated mice. **, p < 0.05 versus DIO control and lean control mice. AU, absorbance units.