TABLE 1.
Electrophysiological characteristics of untreated, HBAR-treated, and shHBAR-treated SAN cells
Cell capacitances were obtained by a built-in function of Axopatch 200B during seal tests. I(Δ−40 mV) is the difference between I(−110 mV) and I(−70 mV) obtained by the voltage ramp protocol as described for Fig. 4E. Values are means ± S.E. ANOVA, analysis of variance; pF, picofarads.
Control SAN cells (n) | HBAR-treated SAN cells (n) | shHBAR-treated SAN cells (n) | One-way ANOVA p value | |
---|---|---|---|---|
Cell capacitance (pF) | 35.9 ± 3.4 (38) | 37.6 ± 2.8 (18) | 44.3 ± 3.5 (15) | p = 0.3435 |
I(Δ−40 mV) (pA/pF) | −7.5 ± 0.9 (38) | −10.0 ± 1.4 (18) | −9.9 ± 1.7 (15) | p = 0.25 |