FIGURE 5.

Summary of enzymatic cross-talk relationships between histone monoubiquitylation and methylation. Left, histone monoubiquitylation sites known to directly influence MTase activity directed toward the indicated histone methylation sites (top) are indicated. Inside, the relevant MTase and the type of cross-talk observed are indicated. ⊕, the ubiquitylated histone directly stimulates the indicated MTase; ⊝, inhibition; ○, no detected stimulation or inhibition. The results presented here and those published by others (see text) are colored in blue and black, respectively.