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. 2012 May 15;287(28):23769–23778. doi: 10.1074/jbc.M112.372425

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Impaired activation and cytotoxic activity of Btk^−/− human NK cells after poly(I:C) stimulation. Highly purified human NK cells from XLA patients (Btk^−/−) and age-matched normal controls were stimulated with poly(I:C) overnight and examined for the expressions of surface activation marker CD69 (A) and intracellular IFN-γ (B) by flow cytometry. C and D, treated NK cells were cocultured with K562 at E/T ratio of 10:1 in the presence of anti-CD107a antibody for 2 h. The surface expression of CD107a on NK cells (C) and specific lysis of target K562 cells (D) were then analyzed by flow cytometry. XLA patients (n = 5) and age-matched normal controls (n = 7) are shown. The data shown are represent for Mean±S.E., *, p < 0.05; **, p < 0.01.