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TLR3-triggered liver hepatitis is attenuated by inhibition of Btk in vivo. WT mice were administered with LFM-A13 (50 mg/kg) and then poly(I:C) (20 μg/g) intraperitoneally. Sera were collected for assays of ALT (A) and AST (B) 20 h later, and serum IFN-γ was examined 8 h after administration (C). Data are means ± S.E. of triplicate experiments. *, p < 0.05; **, p < 0.01. D, 18 h later, liver necrosis and infiltration of lymphocytes were observed after hematoxylin-eosin staining.
