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G231D mutation disrupts template DNA and dNTP binding pocket. A and C, binary (open, no dNTP bound, Protein Data Bank code 1bpx) and B and D, ternary (closed, dNTP bound, Protein Data Bank code 2fms) crystal structures showing 231D pol β (blue) superimposed over WT pol β (red). A and B show residue 231. C and D show the dNTP binding pocket of 231D pol β (blue, cyan, and pink) superimposed over WT pol β (red, orange, and yellow).
