Table 2.
Thirty-three expression traits regulated by type 2 diabetes SNPs
| SNP | Adjacent gene | Expression trait | T2D coexpression rank | ΔRank |
|---|---|---|---|---|
| rs2237892 | KCNQ1 | KCNQ1 | 1 | 654 |
| rs2237897 | ||||
| rs2237892 | KCNQ1 | TNNT3 | 3 | 1,265 |
| rs1111875 | IDE | 23 | 2,508 | |
| rs5015480 | ||||
| rs1111875 | CYP26A1 | 27 | 2,674 | |
| rs5015480 | ||||
| rs4607103 | ADAMTS9 | 34 | 2,840 | |
| rs12255372 | TCF7L2 | VTI1A | 35 | 2,843 |
| rs4506565 | TCF7L2 | CASP7 | 42 | 3,302 |
| rs7895340 | ||||
| rs11196205 | ||||
| rs7901695 | ||||
| rs12255372 | TCF7L2 | GPAM | 43 | 3,428 |
| rs5015480 | PDLIM1 | 48 | 3,603 | |
| rs1111875 | ||||
| rs2237897 | KCNQ1 | TH | 49 | 3,610 |
| rs7961581 | TSPAN8 | 51 | 3,635 | |
| rs864745 | JAZF1 | TAX1BP1 | 101 | 5,108 |
| rs10010131 | WFS1 | MRFAP1 | 138 | 5,504 |
| rs564398 | CDKN2A | 145 | 5,565 | |
| rs10010131 | WFS1 | CPZ | 286 | 6,449 |
| rs1111875 | TMEM20 | 347 | 6,701 | |
| rs5015480 | ||||
| rs12779790 | DHTKD1 | 471 | 7,012 | |
| rs2237897 | KCNQ1 | SLC22A18 | 488 | 7,047 |
| rs4506565 | TCF7L2 | DCLRE1A | 748 | 7,483 |
| rs7903146 | ||||
| rs7901695 | ||||
| rs10010131 | WFS1 | JAKMIP1 | 1,288 | 7,748 |
| rs564398 | PTPLAD2 | 1,409 | 7,774 | |
| rs2237892 | KCNQ1 | CARS | 1,414 | 7,779 |
| rs2237892 | KCNQ1 | NAP1L4 | 1,955 | 7,864 |
| rs7961581 | TMEM19 | 2,243 | 7,842 | |
| rs4607103 | PSMD6 | 2,630 | 7,790 | |
| rs4506565 | TCF7L2 | PDCD4 | 3,496 | 7,445 |
| rs7901695 | ||||
| rs7903146 | ||||
| rs2237892 | KCNQ1 | MRGPRE | 3,615 | 7,394 |
| rs13266634 | SLC30A8 | THRAP6 | 4,001 | 7,211 |
| rs7578597 | THADA | ZFP36L2 | 4,266 | 7,117 |
| rs12255372 | TCF7L2 | RBM20 | 4,870 | 6,788 |
| rs864745 | JAZF1 | HOXA13 | 5,330 | 6,535 |
| rs10010131 | WFS1 | STK32B | 5,457 | 6,470 |
| rs12779790 | SEC61A2 | 7,895 | 4,828 |
ΔRank, the difference between type 2 diabetes coexpression rank and background rank; T2D coexpression rank, the rank of each gene’s type 2 diabetes coexpression score