TABLE 5.
Percent Sensitivity (Se) and Specificity (Sp) of Image Analysis of Nipple Aspirate Fluid (NAF) and Mammary Ductoscopy (MD) Samples
| All cases (N=39) |
PND1 (N=20) |
No PND (N=19) |
||||
|---|---|---|---|---|---|---|
| Se | Sp | Se | Sp | Se | Sp | |
| NAF | ||||||
| - Aneuploid | 31 | 88 | 0 | 83 | 36 | 100 |
| - Hypertetraploid2 | 31 | 96 | 0 | 94 | 36 | 100 |
| - SPF3 > 20 | 46 | 88 | 50 | 83 | 45 | 100 |
| MD | ||||||
| - Aneuploid | 38 | 85 | 50 | 78 | 36 | 100 |
| - Hypertetraploid | 38 | 88 | 0 | 89 | 45 | 88 |
| - SPF > 20 | 31 | 73 | 50 | 67 | 27 | 88 |
| NAF and/or MD | ||||||
| - Aneuploid | 46 | 85 | 50 | 72 | 45 | 100 |
| - Hypertetraploid | 46 | 85 | 0 | 83 | 55 | 88 |
| - SPF > 20 | 46 | 69 | 50 | 61 | 45 | 100 |
1
PND: pathologic spontaneous nipple discharge
2
Diploid defined as DNA Index (DI) = 0.8-1.2, aneuploid as any value above or below diploid. The scores are based on overall DI. Hypertetraploidy is defined as any case that has one or more cells with a DI > 2.0.
3
SPF: S phase fraction