Table 2.

The interaction of single nucleotide polymorphisms with smoking status in the Health, Aging and Body Composition Study^a

Population	Phenotype	SNP	Gene	Function	P-valueb	SNP Type	Key Findingsc
European Americans	ppFEV1	rs9787810	PRDX5	Peroxidase Activity	0.0001	5’ region	CS: ppFEV111% lower for TT/TC vs. CC; d FS: ppFEV13% higher for TT/TC vs. CC; NS: ppFEV1 3% lower for TT/TC vs. CC.
	FEV1/FVC	rs11631100	IDH3A	Reducing Equivalents	0.0003	Intron	CS: ratio higher (by 6) for AA vs. AG/GG; FS, NS: ratio does not differ by genotype.
		rs9787810	PRDX5	Peroxidase Activity	0.0003	5’ region	CS: ratio lower (by 3) for TT/TC vs. CC FS, NS: ratio does not differ by genotype.
African Americans	ppFEV1	NONE
	FEV1/FVC	rs8030346	IDH2	Reducing Equivalents	0.0006	Intron	CS: ratio lower (by 3) for TT and (by 4) for CT (both vs. CC); FS: ratio higher (by 7) for TT and (by 4) for CT (both vs. CC); NS: ratio does not differ by genotype
		rs6107100	IDH3B	Reducing Equivalents	0.000005	Intron	CS: ratio higher (by 6) for AC vs. AA/CC FS, NS: ratio does not differ by genotype
		rs6037255	IDH3B	Reducing Equivalents	0.001	Intron	CS: ratio higher (by 5) for TT/TG vs. GG FS: ratio higher (by 2) for TT/TG vs. GG NS: ratio does not differ by genotype
		rs7549530	MGST3	Glutathione S-Transferase	0.001	5’ region	CS: ratio lower (by 5) for CG vs. CC/GG FS: ratio lower (by 2) for CG vs. CC/GG NS: ratio does not differ by genotype
		rs2042286	SEPW1	Selenoprotein	0.0006	3’ region	CS: ratio higher (by 5) for TT/TC vs. CC FS, NS: ratio does not differ by genotype

^aAll results with FDR-adjusted p-value <0.05

^bNominal p-values shown

^cAbbreviations: CS (current cigarette smokers); FS (former cigarette smokers).

^dCurrent smokers who were either homozygous (TT) or heterozygous (TC) for the minor allele had an 11% lower percent predicted FEV₁ than current smokers that were homozygous for the major allele (CC).