Table 1.
Description of Drug-Disease Interactions Identified by the HEDIS Drug-disease Interaction Measure
| Disease States (N with condition/ disease) |
Drugs to Avoid | N (% With Condition) |
% Exposure 2006 in NCQA Study using Medicare data16 |
|---|---|---|---|
| Dementia (N=131,808) |
Anticholinergics, tricyclic antidepressants |
26,640 (20.2) | 24.6 |
| Fall or Hip Fracture (N=54,393) |
Antipsychotics, tricyclic antidepressants, sleep agents |
8,806 (16.2) | 14.6 |
| Chronic Renal Failure (N=154,278) |
NSAIDS | 13,165 (8.5) | 9.5 |
| Prevalence of 1 or more Rx-DIS overall (N=305,041) |
46,481 (15.2%) | 19.4 |
Examples of anticholinergics include diphenhydramine, dicyclomine, promethazine, cyclobenzaprine, chlorpheniramine, and oxybutynin.
Results from a National Committee on Quality Assurance (NCQA) study examining Drug-Disease Interaction exposure based on the HEDIS measure in 2006 using Medicare data.16