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. Author manuscript; available in PMC: 2012 Jul 6.
Published in final edited form as: Annu Rev Neurosci. 2011;34:601–628. doi: 10.1146/annurev-neuro-060909-153200

Table 5. Summary of the behaviors, physiological responses, neural circuits, and receptors for the actions of dopamine antagonists.

Drugs Behavioral and physiological responses Possible neural circuit mechanisms Receptors
Haloperidol, Droperidol Antinausea, antiemesis Blockade of D2 receptors in chemotactic trigger zone in area postrema Dopamine
Catalepsy, tremor, rigidity Blockade of D1 and D2 receptors in striatum leading to a net increase in inhibition from globus pallidus to thalamus, leading to reduced activity in motor cortex
Loss of affect and emotional expression Loss of facial muscle control due to antidopaminergic activity in nigrostriatal pathway and decreased affect from actions in mesolimbic and mesocortical pathways
Sedation Combined inhibition of arousal, mesolimbic and mesocortical dopaminergic pathways
Antinausea, antiemesis Antihistaminergic activity in nucleus tractus solitarius Histamine
Antinausea, antiemesis Antiserotinergic activity in nucleus tractus solitarius and chemotactic trigger zone Serotonin