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. 2012 May 2;32(7):1393–1415. doi: 10.1038/jcbfm.2012.53

Figure 4.

Figure 4

Cross-sectional patterns of lesion enhancement in patients with multiple sclerosis (MS) as detected by magnetic resonance imaging (MRI). (A) Pre-Gd T2SE images showing MS lesions. (B) Pre-GdT1-w images showing hypointensity of some of the MS lesions. (C) Some lesions are Gd-DTPA positive. (D) Post-USPIO images show a Gd-DTPA-positive/USPIO ring-enhancing lesion (arrow) and a Gd-DTPA-negative/focally USPIO-positive lesion (arrowhead). (Figure reprinted with permission from Vellinga et al, 2008.) USPIO, ultrasmall superparamagnetic iron oxide; Gd-DTPA, gadolinium-diethylenetriaminepentaacetic acid.