Figure 6.

Early detection of amyloid-β as damage-associated molecular pattern (DAMP) and microglia activation in patients with mild cognitive impairment by positron-emission tomography (PET). [¹¹C]-(R)-PK11195 binding potentials (BPs) and corresponding [¹¹C]PIB ratio images in two patients with PIB-positive mild cognitive impairment (MCI). MCI-I has normal PK binding and MCI-II has increased PK binding suggesting that Aβ deposition may be related but also unrelated to microglia activation at very early disease stages. The detection of microglial activation in patients with MCI suggests that anti-inflammatory therapies may be relevant to the prevention of AD. (Figure reprinted with permission from Okello et al, 2009.)