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Illustration of the volume-of-interest (VOI) generation. On the left is shown a gray matter segmentation (gray) for a young subject with the generic mask for F-M1 (frontal lobe without primary motor area) (shown in red) overlaid. These binary masks are multiplied to create the VOI and are shown on the right (white). This customized VOI is superimposed on the parametric cerebral blood flow (CBF) image of the same subject.
