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. 2012 Jun 18;109(27):10996–11001. doi: 10.1073/pnas.1202885109

Fig. 4.

Fig. 4.

Model to explain melarsoprol and pentamidine transport in T. brucei. Four T. brucei transporters have been linked to the control of melarsoprol and or pentamidine susceptibility. Both drugs enter the cell through AT1/P2 (Tb927.5.286b) and AQP2. HA1-3 (Tb927.10.12500–10, only two annotated in the reference genome) is specifically linked to pentamidine susceptibility and generates the proton motive force required for pentamidine symport via AQP2. Efflux of the toxic melarsoprol adduct, Mel T, is via MRPA (Tb927.8.2160). The AT1/P2 and AQP2 channels transport the drugs with different efficiencies as indicated by the weighted arrows. AT1/P2 and MRPA have not been localized. FP, flagellar pocket; Mel T, melarsoprol–trypanothione adduct. The homology model for AT1/P2 is restricted to residues 340–454.