Skip to main content
. 2012 Jun 18;109(27):10972–10977. doi: 10.1073/pnas.1200106109

Fig. 5.

Fig. 5.

Extent of epigenetic reprogramming by 3′Eα. Chromatin modifications at the wild-type or rearranged Mycn locus in primary or tumor cells. (I) Composite analysis of H3K4me3, H2BK5Ac, H3K9Ac, and H3K27Ac deposition at the Igh/Mycn inverted locus. (II) The same analysis for modifications H2AZ, H2BK120Ac, H3K36me2, H4K8Ac, and H4K91Ac. The black arrow denotes the extent of epigenetic remodeling above background signal, which was measured in primary activated B cells (III). Although the Mycn locus is not rearranged in primary cells, for comparative purposes the compiled epigenetic modifications in III are shown over a genome carrying the same translocation as in I and II.