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. 2012 Jun 18;109(27):10972–10977. doi: 10.1073/pnas.1200106109

Fig. 6.

Fig. 6.

“Warping” model of 3′Eα activity. Our studies indicate that the 3′Eα acts over half a megabase of chromatin space, with oncogenes such as Myc being deregulated by translocations that fall within this genomic window. Non-Ig genes downstream of the enhancer might be protected from 3′Eα activity by the hs5-7 insulator.