Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Role of the Dll4-Notch axis in cardiometabolic disorders. The Dll4-Notch axis activates the NF-κB pathway. Activation of NF-κB increases the expression of MCP-1, which leads to the accumulation and proinflammatory activation of macrophages in organs such as arteries and adipose tissue. Accumulation of activated macrophages contributes to the pathogenesis of cardiometabolic disorders, including atherosclerotic vascular diseases and insulin resistance.
