TABLE 1.
Genistein and complement 3 concentrations in serum and nipple aspirate fluid (NAF) before and after isoflavone interventiona
| 20 mg Isoflavones |
70 mg Isoflavones |
|||||
|---|---|---|---|---|---|---|
| Before | After | Δ | Before | After | Δ | |
| Serum genistein (ng/ml) | ||||||
| Mean | 17.3 (12) | 172.8 (12) | 155.5 (12) | 26.3 (15) | 620.5 (15) | 594.3 (15) |
| SD | 16.7 | 85.0 | 92.5 | 48.2 | 360.6 | 367.3 |
| Median | 15.8 | 171.1 | 143.6 | 14.8 | 528.5 | 507.3 |
| Serum C3 (ng/ml) | ||||||
| Mean | 24,138 (14) | 23,252 (14) | −886 (14) | 18,432 (17) | 16,157 (17) | −2,275 (17) |
| SD | 13,395 | 12,478 | 6,843 | 12,512 | 12,837 | 15,594 |
| Median | 27,673 | 17,828 | 446 | 14,191 | 12,040 | −1,925 |
| NAF C3 (ng/mg)b | ||||||
| Mean | 0.37 (9) | 0.15 (9) | −0.23 (9) | 0.35 (14) | 0.51 (14) | 0.16 (14) |
| SD | 0.37 | 0.15 | .43 | 0.44 | 0.95 | 0.81 |
| Median | 0.23 | 0.070 | −0.03 | 0.14 | 0.12 | −0.00 |
| NAF C3 (ng/ml) | ||||||
| Mean | 49.6 (9) | 20.5 (9) | −29.1 (9) | 48.4 (14) | 62.2 (14) | 13.8 (14) |
| SD | 65.1 | 30.4 | 77.5 | 70.7 | 152.9 | 113.5 |
| Median | 17.6 | 15.5 | −4.3 | 23.4 | 13.1 | −0.4 |
a
The values were obtained as follows: The change (Δ) that occurred in each individual (after treatment — before treatment) was calculated. Then the mean, SD, and median values for the changes were calculated. Change in serum genistein was significant for both the low- and high-dose isoflavones groups (P < 0.01 for both). Change in serum C3, NAF C3 (ng/ml), and NAF C3 (ng/mg) were not significant for either dosage group. Numbers in parentheses represent subjects with matched before and after treatment samples.
b
ng/mg: ng C3 per mg total NAF protein.