Table 2.

Association of Fetuin-A with Incident Diabetes in the Cardiovascular Health Study

Range (g/L)	Fetuin-A Quartiles				Continuous
	I	II	III	IV	Per SD (0.10 g/L) greater
	≤0.41	>0.41–0.47	>0.47–0.53	>0.53		P-value
Events/ Person Years at Risk	56/8811	71/8913	93/8989	85/8670
Model 1*; HR (95% CI)	1.00 (Ref)	1.31 (0.92–1.87)	1.75 (1.25–2.45)	1.69 (1.20–2.40)	1.23 (1.09–1.38)	0.001
Model 2**; HR (95% CI)	1.00 (Ref)	1.27 (0.89–1.80)	1.72 (1.23–2.41)	1.56 (1.10–2.21)	1.19 (1.06–1.34)	0.003
Model 3†; HR (95% CI)	1.00 (Ref)	1.16 (0.81–1.65)	1.52 (1.08–2.13)	1.37 (0.95–1.96)	1.13 (1.00–1.28)	0.05

Abbreviations: HR=Hazard Ratio; CI=confidence interval; Ref=reference category

^*Model 1 is adjusted for age, sex, race, and field center site

^**Model 2 is adjusted for model 1 variables plus physical activity, smoking, alcohol use, eGFR, and prevalent CVD

^† Model 3 is adjusted for model 2 variables plus body mass index, waist circumference, hypertension, triglycerides, HDL, serum albumin, and CRP.