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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Arch Biochem Biophys. 2011 Dec 16;518(1):53–60. doi: 10.1016/j.abb.2011.10.022

Fig. 3. IOP response to 5 μg 1,25-(OH)2D3 after pretreatment with pilocarpine (Pilo) to block uveoscleral outflow.

Fig. 3

Monkeys were treated twice daily with 5 μg 1,25-(OH)2D3 to both eyes. Prior to the 5th 1,25-(OH)2D3 treatment on day 3, one eye was treated with 1mg Pilo to contract the ciliary muscle and block uveoscleral outflow and after 30 min both eyes received the fifth 5 μg treatment of 1,25-(OH)2D3 (see Materials and Methods for details). White squares represent the IOP change in the eye treated with 1,25-(OH)2D3 only and black circles represent the IOP change in the eye pretreated first with pilocarpine and then treated with 1,25-(OH)2D3. After the 5th treatment with 1,25-(OH)2D3, there was no apparent suppression of the IOP response to 1,25-(OH)2D3 as a result of pilocarpine pretreatment. Data are mean ± sem. Significantly different from 0.0: *p<0.05, minimum. IOP (mmHg ± sem) prior to the first treatment on day 1 was: 1,25-(OH)2D3 = 18.9 ± 1.0; 1,25-(OH)2D3+Pilo = 19.1 ± 0.9.