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. Author manuscript; available in PMC: 2013 Jul 4.
Published in final edited form as: J Am Chem Soc. 2012 Jun 22;134(26):10822–10832. doi: 10.1021/ja211368u

Figure 1.

Figure 1

Amino acid sequence alignment of EcFtnA, PfFtn, DvFtn, HuHf and BfMf. EcFtn numbering system is used throughout the manuscript. All three prokaryotic Ftn’s (EcFtn, PfFtn and DvFtn) share the same sequence numbers up to residue 165 with variation on the C-terminal extensions. The two eukaryotic H-type ferritins (HuHF and BfMF) have different N- and C-terminal extensions. The conserved residues are boxed in red. The residues that are conserved only in the bacterial ferritins are boxed in blue. The triangles indicates residues that are ligands to iron sites A and B. The stars indicates residues that are ligands to iron site C. Labels (A, B and C) for the three Fe binding sites are in accord with those designated by Stillman et al.9