Effect of diet intervention with either a normal diet (ND) or high-fat diet (HFD) on body weight gain and tissue mass change. A–B, Effect of HFD on body weight gain (A) and heart weight (B). C, Effect of HFD on fat tissue mass change. eWAT, epididymal white adipose tissue; iWAT, inguinal white adipose tissue; rWAT, retroperitoneal white adipose tissue; iBAT, interscapular adipose tissue. n=4 per group. *p < 0.05, **p < 0.01 compared with the ND group.