Table 1.
Effects of Vehicle (VEH) or Buspirone (BUS) on Histological Outcome after TBI
| Groups | CA1 | CA3 | Lesion volume (mm3) |
|---|---|---|---|
| TBI+VEH (1.0 mL/kg) | 34.4±2.2 | 41.0±6.0 | 43.1±2.3 |
| TBI+BUS (0.01 mg/kg) | 35.9±4.6 | 41.7±3.4 | 42.0±2.4 |
| TBI+BUS (0.05 mg/kg) | 36.3±5.6 | 44.1±5.9 | 41.0±1.7 |
| TBI+BUS (0.1 mg/kg) | 42.1±4.6 | 48.3±4.4 | 38.3±2.3 |
| TBI+BUS (0.3 mg/kg) | 43.7±10.1 | 54.2±5.4 | 33.0±2.2* |
| TBI+BUS (0.5 mg/kg) | 36.9±3.4 | 42.1±8.7 | 43.2±1.6 |
| Sham | 99.6±2.5** | 100.6±1.1** |
**
p<0.0001 versus all TBI groups.
*
p<0.003 versus TBI+VEH, TBI+BUS (0.01 mg/kg), and TBI+BUS (0.5 mg/kg).
Mean (±standard error of the mean) number of normal-appearing hippocampal neurons (expressed as a percentage of the contralateral hippocampus), and cortical lesion volume quantified 3 weeks after TBI or sham injury.
TBI, traumatic brain injury; BUS, buspirone; VEH, vehicle.