Table 1.
Particle size and particle size distribution of (A) methotrexate nanoparticles prepared by SEDS, and MTX-PLLA-PEG-PLLA microspheres from (B) microencapsulation process and (C) coprecipitation process with a drug dose of 10%
| Samples | D10 (nm) | D50 (nm) | D90 (nm) | Span | Mean size (nm) |
|---|---|---|---|---|---|
| A | 52 | 79 | 110 | 0.73 | 86 |
| B | 329 | 520 | 807 | 0.92 | 545 |
| C | 245 | 361 | 583 | 0.94 | 389 |
Abbreviations: SEDS, solution-enhanced dispersion by supercritical fluid process; MTX-PLLA-PEG-PLLA, methotrexate-poly(L-lactide)-poly(ethylene glycol)-poly (L-lactide).