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. 2012 Mar 27;22(7):1102–1104. doi: 10.1038/cr.2012.51

Figure 1.

Figure 1

Summarization of reported mechanisms linking IDH mutation to tumorigensis. Regulation of α-KG-dependent dioxygenases by R-2-HG is likely to play a major role in the pathophysiology of tumors with IDH mutation.