TABLE 2.

Blood half-lives of ¹²³I-labeled T84.66 scFv-Fc antibody fragments in hFcRn mice

Antibody fragment	Aαa	Aβa	k1b	k2b	t½ c	t½ c	AUCd
	%ID/g	%ID/g	1/h	1/h	h	h
Wild type	29.6	20.3	0.2497	0.01737	2.776	39.89	938.3
H435R	22.6	14.4	0.2042	0.0165	3.394	42.02	710.6
H435Q	21.2	22.2	1.244	0.06761	0.5573	10.25	361.6
I253A	8.7	28.6	0.9073	0.07431	0.764	9.328	427.1
H310A	13.2	17.6	1.108	0.09282	0.6258	7.468	217.3
H310A/H435Q	52.8	26.1	3.766	0.1083	0.1841	6.401	288.2

^a Amplitudes of the two components are given by Aα and Aβ, where the sum of Aα and Aβ is the total injected dose/g (%ID/g).

^b k₁ and k₂ are first-order rate constants for distribution and elimination, respectively.

^c t½α and t½β are the distribution and elimination phase half-lives and are calculated by ln2/k₁ and ln2/k₂, respectively.

^d Area under the curve is a time integral of the blood uptake (%ID/g·h).