FIGURE 1.
Structure of LST1/A. A, alignment of amino acid sequences of LST1/A orthologues from human (Homo sapiens, GenBankTM accession number: NP_995311), cattle (Bos taurus, XP_002702922), dog (Canis familiaris, XP_848911), pig (Sus scrofa, XP_002702922), and mouse (Mus musculus, O08843). The transmembrane domain, the putative palmitoylation site, ITIM, and ITIM-like motifs are highlighted. B, graphical depiction of human LST1/A dimer structure with a disulfide bridge. C, alignment of amino acid sequences of ITIM and ITIM-like region of human LST1/A with a corresponding region from members of CD33-related Siglec family. Identical (*) and more (:) or less (.) similar amino acids at particular positions in all sequences are indicated. The distance in amino acids (AA) separating these motifs is shown.