FIGURE 4.

miR-143 was inversely associated with HK2 protein level in human lung cancer samples. A, detection of miR-125a/b and miR-143 levels by quantitative PCR. Values below zero indicate miRNAs with low expression in lung tumor tissue as compared with paired normal lung. B, Western blot analyses of HK2 levels in human lung cancer specimens with paired normal lungs. N, normal; T, tumor. C, statistical analysis of correlation between miR-125a/b/143 and HK2 protein level. HK2 protein level was divided into three groups (low, moderate, and high) according to the ratio of HK2 protein level in tumor to normal counterpart. Correlation coefficients (R) and p values were shown.