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. 2012 May 4;287(27):23024–23033. doi: 10.1074/jbc.M112.367011

FIGURE 6.

FIGURE 6.

Exercise specifically rescued HFD-induced deterioration of neprilysin activity. A, In vitro enzyme activity assay of neprilysin using the fluorescence substrate. The activity of neprilysin in APP-HFD mice tends to be decreased when compared with that in control APP mice (F(4, 15) = 5.58, p = 0.061). On the other hand, neprilysin activity in APP-HFD+Ex mice was significantly higher than that in APP-HFD mice (*, p = 0.023) or that in APP-HFD+Dc mice (*, p = 0.032). B, significant correlation was established by comparing the activity of neprilysin and the level of cerebral Aβ deposition, using Pearson's correlation coefficients. The activity of neprilysin was negatively correlated with the level of accumulated Aβ (r = −0.782, *, p = 0.00003).