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. 2012 May 21;287(27):22450–22462. doi: 10.1074/jbc.M112.339663

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Effect of inhibitors and M6P-IGF2R-derived peptide 18–36 on Plg internalization in the TCL-598 cell line. Control-silenced (shCTR) and M6P-IGF2R-silenced (shM6P-IGF2R) TCL-598 cells were preincubated at 37 °C for 60 min with or without monensin (30 μmol/liter) and then subjected for 90 min to the internalization assay with Plg-AF488 (100 nmol/liter) as described in Fig. 6 in the presence of either peptide 18–36 (pep18–36; 20 μmol/liter), control scrambled peptide (pepSCR; 20 μmol/liter), or tranexamic acid (TA; 5 mmol/liter). Values of internalization were calculated as percentage differences in the geometric mean fluorescence intensity values relative to the geometric mean fluorescence intensity value (MFI) obtained for control cells without any additives (100%).