Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Fibril formation of PABPN1 variants lacking the C-terminal domain. A, samples were incubated at 37 °C at a protein concentration of 0.5 mm. Squares indicate the presence of 5% (w/w) seeds derived from fibrils of the N-terminal domain of PABPN1 (N-(+7)Ala); circles indicate the absence of seeds. Black, WT-ΔC49; white, ΔAla-ΔC49; and gray, (+7)Ala-ΔC49. B, zoom into kinetics until day 17 with unseeded samples.
