Table 4. Diagnostic value of Cough ≥2 weeks, any symptom, and CXR.

Screening strategy (strategy # as in Table 1 )	TB cases with positive screen	Participants without TB with positive screen	Sensitivity(%) (95%CI*)	Specificity(%) (95%CI)	PPV(%) (95%CI)	AUC†
Total N	123	20,443
1. Cough ≥2 weeks§	64	2,200	52 (41–63)	89 (88–90)	2.8 (2.0–3.2)	0.71
in HIV-positive	36		69 (56–83)
in HIV-negative	20		41 (25–57)
in HIV-unknown	8		36 (17–59)
2. Any symptom of any duration or severity§	111	13,878	90 (84–95)	32 (30–34)	0.8 (0.6–1.0)	0.61
in HIV-positive	50		96 (87–100)
in HIV-negative	40		82 (68–91)
in HIV-unknown	21		95 (77–100)
8. CXR – any abnormality**	113	5,229	94 (88–98)	73 (68–77)	2.1 (1.5–2.7)	0.83
in HIV-positive	47		92 (81–98)
in HIV-negative	48		100 (93–100)
in HIV-unknown	18		86 (68–100)
11. Cough ≥2 weeks or any CXR abnormality§	119	8,702	97 (92–99)	57 (55–60)	1.4 (1.1–1.7)	0.79
in HIV-positive	52		100 (93–100)
in HIV-negative	49		100 (93–100)
in HIV-unknown	18		82 (60–95)

CI = Confidence Interval CXR = Chest radiograph.

^*Where the design effect was ≤1 CI’s were not adjusted for cluster design but binomial exact CI presented.

^†AUC = Area under the receiver operating characteristic curve.

^§Denominator for HIV-positive n = 52, HIV-negative n = 49, HIV-unknown n = 48.

^**3 cases did not have a CXR, 1HIV+, 1HIV-, 1HIVunknown, so denominators are 120, 51, 48 and 21 respectively. For specificity: 1347 missing records.