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. 2012 Jul 6;7(7):e39398. doi: 10.1371/journal.pone.0039398

Figure 9. IGFBP-3 activates PI3kinase via scavenger receptor-B1.

Figure 9

A. PI3K activity was evaluated in HMVECs and expressed as percent control. PI3K activity was enhanced by up to 7-fold by IGFBP-3, which was significantly decreased by pretreatment with scavenger receptor-B1 neutralizing antibody (SRB1-Ab) (P<0.05, nā€Š=ā€Š3). B. Expression of the novel cell death receptor was significantly lower in HMVECs compared to the expression of scavenger receptor-B1 (SRB1) (P<0.0001, nā€Š=ā€Š3).