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. 2012 Jul 6;7(7):e39355. doi: 10.1371/journal.pone.0039355

Figure 5. Chaotic motifs described by Inline graphic.

Figure 5

Inline graphic distributions of the chaotic GRNs of Figs.1 and 2. A for Fig.1A; B for Fig.1D; C for Fig.2A; D for Fig.2B; E for Fig.2C. The numbers associated to all cross interactions indicate the Inline graphic of Eq.(7). The total period of measurement is about Inline graphic cycles of chaotic orbits. It is shown that most of the interactions reducible for chaos have almost zero Inline graphic, while all the interactions irreducible for chaos in the chaotic motifs in Fig.1D and Fig.2C have sufficiently large Inline graphic. Note that, the two interactions Inline graphic and Inline graphic in D have comparable Inline graphic. Discarding different one of them can construct different chaotic motifs (motifs (22) and (67) in Fig. S1 by discarding Inline graphic and Inline graphic, respectively). On the other hand, both the interactions of Inline graphic and Inline graphic in D are important for the competition between the two loops and thus essential for chaos. There is only one loop in the GRN after removal of Inline graphic (breaking condition (i)); and the PFL is included in the NFL after deletion of Inline graphic (breaking condition (iii)), and both of the two operations can securely suppress chaotic motions.