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Tpp1(−/−) mice were administered indicated amounts of enzyme via tail vein injection and tissues collected after 24 hours. TPP1 specific activity (activity/mg protein) was normalized to that of wild-type controls. Unmodified TPP1, open bars; OX-TPP1, filled bars, DG-TPP1, gray bars. Sample size as in Table 1. Error bars represent standard deviation.
