Fig. 2.

Gene and linkage disequilibrium plot for the chromosome 15 SNPs associated with insulin clearance. Genes are indicated by arrows (arrow size not to scale). The locations of the genotyped SNPs relative to the genes are indicated. The linkage disequilibrium plot beneath the genes displays D′ values (%) for each pair of SNPs in the box at the intersection of the diagonals from each SNP. The bright red blocks indicate D′ = 1 (100%) for the corresponding pair of variants with an LOD score ≥2. The boxes with lighter shades of red indicate D′ <1, with an LOD score ≥2. The SNPs consist of a single SNP at MEGF11, plus two distinct blocks of SNPs. The region of the first block of SNPs is expanded to provide details. SNPs rs12899971 and rs2301249 are intronic; rs7085 resides in the 3′ untranslated region of CSK. SNPs that do not have rs numbers are indicated by genomic coordinates (NCBI Genome Build 36.3, www.ncbi.nlm.nih.gov/genome/guide/human/release_notes.html)