Table 2.
Characteristics of the GWAS datasets
| Cases | Controls | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (N) |
Female (N, %) |
Age at onset (mean ± SD) |
Age at exam (mean ± SD) |
APOE ε4 (allele %) |
Controls (N) |
Female (N, %) |
Age at exam (mean ± SD) |
APOE ε4 (allele %) |
|
| ACT | 566 | 357(63%) | 83.90 (4.8) | 84.72 (4.9) | 0.26 | 1696 | 947 (56%) | 81.08 (6.0) | 0.11 |
| ADC1 | 1566 | 850 (54%) | 72.47 (7.1) | 81.61 (7.0) | 0.42 | 515 | 305 (59%) | 75.00 (8.0) | 0.16 |
| ADC2 | 738 | 377 (51%) | 73.19 (7.1) | 80.06 (7.2) | 0.39 | 160 | 110 (69%) | 75.68 (7.9) | 0.16 |
| ADNI | 268 | 113 (42%) | 75.30 (7.2) | 77.96 (6.5) | 0.42 | 173 | 70 (40%) | 78.6 (5.5) | 0.14 |
| GenADA | 669 | 380 (57%) | 74.59 (6.2) | 80.36 (6.2) | 0.38 | 713 | 456 (64%) | 74.21 (7.0) | 0.13 |
| UM/VU/MSSM | 1186 | 764 (64%) | 74.06 (7.8) | 77.48 (6.9) | 0.36 | 1135 | 696 (61%) | 74.00 (8.3) | 0.12 |
| MIRAGE | 509 | 324 (64%) | 71.16 (6.5) | 75.97 (6.6) | 0.36 | 753 | 440 (58%) | 72.04 (7.2) | 0.23 |
| NIA-LOAD | 1811 | 1176 (65%) | 73.57 (6.7) | 82.49 (7.1) | 0.46 | 1575 | 947 (60%) | 73.99 (8.5) | 0.20 |
| OHSU | 132 | 81 (61%) | 86.10 (5.5) | 90.40 (5.2) | 0.23 | 153 | 84 (55%) | 83.86 (7.6) | 0.08 |
| TGEN2 | 864 | 633 (73%) | 74.91 (7.2) | 82.00 (7.6) | 0.40 | 493 | 186 (38%) | 80.19 (8.7) | 0.11 |
| TOTAL | 8309 | 5055 (61%) | -- | -- | -- | 7366 | 4241 (58%) | -- | -- |