Table 3.
Odds ratio of indices of insulin sensitivity and insulin secretion for predicting the 7.8-year incidence of diabetes by multiple logistic regression analysis
| Matsuda index | ΔI0–30/ΔG0–30 | I/GAUC 60–120 | S1PhOGTT | S2PhOGTT | C statistic | P | |
|---|---|---|---|---|---|---|---|
| Model 1 | 0.24 (0.18–0.31) | 0.28 (0.22–0.37) | – | – | – | 0.875 | – |
| Model 2 | 0.09 (0.06–0.14) | – | 0.21 (0.15–0.28) | – | – | 0.858 | 0.076 |
| Model 3 | 0.11 (0.07–0.17) | 0.41 (0.31–0.54) | 0.37 (0.26–0.54) | – | – | 0.882 | 0.044 |
| Model 4* | 0.16 (0.10–0.25) | 0.43 (0.32–0.58) | 0.46 (0.31–0.68) | – | – | 0.888 | < 0.001 |
| Model 5 | 0.11 (0.08–0.16) | – | – | 0.24 (0.18–0.32) | – | 0.873 | 0.314 |
| Model 6 | 0.15 (0.10–0.23) | 0.50 (0.32–0.79) | – | 0.46 (0.28–0.76) | – | 0.877 | 0.792 |
| Model 7 | 0.10 (0.07–0.14) | – | – | – | 0.22 (0.16–0.30) | 0.873 | 0.556 |
| Model 8 | 0.14 (0.09–0.22) | 0.51 (0.33–0.80) | – | – | 0.44 (0.25–0.75) | 0.877 | 0.610 |
Odds ratios expressed for 1 standard deviation unit increase. Age, sex, ethnicity, BMI and family history of diabetes were included as covariates in all eight models.
*
Impaired glucose tolerance (IGT) was also added to Model 4 as a covariate.
I0–30/G0–30, insulinogenic index from 0 to 30 min; I/GAUC 60–120, ratio of area under the insulin curve to area under the glucose curve from 60 to 120 min; and S1PhOGTT and S2PhOGTT, Stumvoll first phase and second phase insulin release, respectively. P-values are for the comparison with Model 1.