Table 2.
Genotype Frequencies of the Two Single-Nucleotide Polymorphism s in Mitogen-Activated Protein Kinase Kinase 4 in Patients and Controls and Their Associations with Cervical Cancer
| |
Controls (n=600) |
Patients (n=471) |
|
||
|---|---|---|---|---|---|
| Genotypes | No. | (%) | No. | (%) | ORa(95% CI) |
| -1304T>G | |||||
| TT | 364 | 60.66 | 326 | 69.21 | 1.00 (Reference) |
| TG | 199 | 33.17 | 128 | 27.18 | 0.71 (0.53–0.92) |
| GG | 37 | 6.17 | 17 | 3.61 | 0.52 (0.30–0.91) |
| Ptrend | 0.004 | ||||
| TG+GG | 236 | 39.33 | 145 | 30.79 | 0.68 (0.52–0.87) |
| -1044A>T | |||||
| AA | 405 | 67.50 | 318 | 67.52 | 1.00 (Reference) |
| AT | 172 | 28.67 | 136 | 28.87 | 1.01 (0.75–1.31) |
| TT | 23 | 38.33 | 17 | 3.61 | 0.92 (0.45–1.62) |
| Ptrend | 0.943 | ||||
| AT+TT | 195 | 32.50 | 153 | 32.48 | 0.99 (0.75–1.31) |
a
Data were calculated by logistic regression analysis with adjustment for age and BMI.
OR, odds ratio; CI, confidence interval.