Table 3.
Stratification Analysis of the Mitogen-Activated Protein Kinase Kinase 4-1304T>G Genotypes by Selected Variables in Cervical Cancer Patients and Controls
| |
Patients (n=487) |
Controls (n=723) |
Adjusted OR (95% CI)a |
|
||
|---|---|---|---|---|---|---|
| TT N (%) | TG+GG N (%) | TT N (%) | TG+GG N (%) | TG+GG versus TT | p-valueb | |
| Age (years) | ||||||
| ≤48 | 220 (68.32) | 102 (31.68) | 244 (62.89) | 144 (37.11) | 0.79 (0.57–1.07) | |
| >48 | 106 (71.14) | 43 (28.86) | 120 (56.60) | 92 (43.40) | 0.53 (0.34–0.83) | 0.16 |
| Body mass index (BMI) | ||||||
| ≤20 | 76 (66.09) | 39 (33.91) | 63 (64.95) | 34 (35.05) | 0.95 (0.54–1.69) | |
| 20–28 | 234 (69.64) | 102 (30.36) | 262 (60.09) | 174 (39.91) | 0.66 (0.49–0.89) | |
| ≥28 | 16 (80.00) | 4 (20.00) | 39 (58.21) | 28 (41.79) | 0.35 (0.11–1.15) | 0.28 |
| Family history of cancer | ||||||
| Positive | 26 (70.27) | 11 (29.73) | 25 (56.82) | 19 (43.18) | 0.56 (0.22–1.40) | |
| Negative | 300 (69.12) | 134 (30.88) | 339 (60.97) | 217 (39.03) | 0.70 (0.54–0.91) | 0.64 |
| Clinical Stage | ||||||
| 0+I | 154 (71.63) | 61 (28.37) | 364 (60.67) | 236 (39.33) | 0.61 (0.44–0.86) | |
| II+III+IV | 172 (67.19) | 84 (32.81) | 364 (60.67) | 236 (39.33) | 0.75 (0.55–1.03) | 0.37 |
| Tumor grade | ||||||
| Low | 29 (67.44) | 14 (32.56) | 364 (60.67) | 236 (39.33) | 0.74 (0.39–1.44) | |
| Intermediate | 145 (67.13) | 71 (32.87) | 364 (60.67) | 236 (39.33) | 0.76 (0.54–1.05) | |
| High | 96 (72.73) | 36 (27.27) | 364 (60.67) | 236 (39.33) | 0.58 (0.38–0.88) | |
| Unknown | 56 (70.00) | 24 (30.00) | 364 (60.67) | 236 (39.33) | 0.66 (0.40–1.10) | 0.79 |
| Histological type | ||||||
| Squamous cell carcinoma | 248 (69.08) | 111 (30.92) | 364 (60.67) | 236 (39.33) | 0.69 (0.52–0.91) | |
| Adenocarcinoma | 17 (68.00) | 8 (32.00) | 364 (60.67) | 236 (39.33) | 0.73 (0.31–1.71) | |
| Adenosquamous carcinoma | 5 (71.43) | 2 (28.57) | 364 (60.67) | 236 (39.33) | 0.62 (0.12–3.21) | |
| Carcinoma in situ | 56 (70.00) | 24 (30.00) | 364 (60.67) | 236 (39.33) | 0.66 (0.40–1.10) | 0.97 |
| HPV infection status | ||||||
| Positive | 53 (69.74) | 23 (30.26) | 364 (60.67) | 236 (39.33) | 0.67 (0.40–1.12) | |
| Negative | 273 (69.11) | 122 (30.89) | 364 (60.67) | 236 (39.33) | 0.69 (0.53–0.90) | 0.92 |
a
ORs were adjusted for age in a logistic regression model.
b
P value of the test for homogeneity between stratum-related ORs for MKK4 gene (-1304 TG+GG vs. TT genotypes).