Table 5.
The Polymorphisms of the GEMIN4 Gene and the Risk of Prostate Cancer in Different clinical Stages
| |
|
Controls (N=244) |
Clinical stage I and II (N=81) |
Clinical stage III and IV (N=219) |
Clinical stage III and IV vs. Clinical stage I and II |
||
|---|---|---|---|---|---|---|---|
| Polymorphism | Genotype and allele | n | n | OR | n | OR | OR |
| CC | 19 | 3 | 1 | 7 | 1 | 1 | |
| CT | 81 | 26 | 2.03 (0.53, 11.52) | 72 | 2.41 (0.90, 7.17) | 1.19 (0.18, 5.68) | |
| TT | 144 | 52 | 2.29 (0.63, 12.52) | 140 | 2.64 (1.02, 7.64) | 1.15 (0.19, 5.28) | |
| C | 119 | 32 | 1 | 86 | 1 | 1 | |
| rs7813 | T | 369 | 130 | 1.31 (0.83, 2.10) | 352 | 1.32 (0.95, 1.83) | 1.01 (0.62, 1.61) |
| TT | 201 | 73 | 1 | 186 | 1 | 1 | |
| TA/AA | 43 | 8 | 0.51 (0.20, 1.17) | 33 | 0.83 (0.49, 1.40) | 1.62 (0.69, 4.25) | |
| T | 445 | 154 | 1 | 405 | 1 | 1 | |
| rs4968104 | A | 43 | 8 | 0.54 (0.21, 1.19) | 33 | 0.84 (0.51, 1.39) | 1.57 (0.69, 4.02) |
| CC | 142 | 41 | 1 | 147 | 1 | 1 | |
| CT | 82 | 30 | 1.27 (0.71, 2.26) | 62 | 0.73 (0.48, 1.11) | 0.58 (0.32, 1.05) | |
| TT | 20 | 10 | 1.73 (0.67, 4.24) | 10 | 0.48 (0.20, 1.13) | 0.28 (0.10, 0.81) | |
| C | 366 | 112 | 1 | 356 | 1 | 1 | |
| rs3744741 | T | 122 | 50 | 1.34 (0.88, 2.01) | 82 | 0.69 (0.50, 0.96) | 0.52 (0.34, 0.80) |
| GG | 182 | 70 | 1 | 176 | 1 | 1 | |
| GC/CC | 62 | 11 | 0.46 (0.21, 0.95) | 43 | 0.72 (0.50, 1.14) | 1.55 (0.73, 3.54) | |
| G | 426 | 151 | 1 | 395 | 1 | 1 | |
| rs2740348 | C | 62 | 11 | 0.50 (0.23, 0.99) | 43 | 0.75 (0.48, 1.15) | 1.55 (0.73, 3.54) |
| TT | 240 | 81 | 1 | 217 | 1 | 1 | |
| TC/CC | 4 | 0 | - | 2 | 0.55 (0.05, 3.91) | - | |
| T | 484 | 162 | - | 436 | 1 | 1 | |
| rs1062923 | C | 4 | 0 | - | 2 | 0.56 (0.05, 3.90) | - |
| CC | 18 | 9 | 1 | 14 | 1 | 1 | |
| CG | 103 | 32 | 0.62 (0.24, 1.74) | 103 | 1.29 (0.57, 2.95) | 2.07 (0.72, 5.69) | |
| GG | 123 | 40 | 0.65 (0.25, 1.78) | 102 | 1.07 (0.47, 2.44) | 1.64 (0.58, 4.44) | |
| C | 139 | 50 | 1 | 131 | 1 | 1 | |
| rs910925 | G | 349 | 112 | 0.89 (0.60, 1.34) | 307 | 0.93 (0.70, 1.25) | 1.05 (0.69, 1.57) |
| CC | 190 | 65 | 1 | 175 | 1 | 1 | |
| CT/TT | 54 | 16 | 0.87 (0.43, 1.67) | 44 | 0.88 (0.55, 1.42) | 1.02 (0.52, 2.08) | |
| C | 434 | 146 | 1 | 394 | 1 | 1 | |
| rs910924 | T | 54 | 16 | 0.88 (0.46, 1.62) | 44 | 0.90 (0.57, 1.40) | 1.02 (0.54, 2.00) |
The bold numbers mean the p-value is <0.05.