TABLE II.
Logistic Regression Analysis of Selected SNPs and Risk of Overall NHL, Diffuse Large B-cell Lymphoma (DLBCL), and Follicular Lymphoma (FL)
| SNP | Genotype | Controls (%) | Overall NHL
|
DLBCL
|
FL
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | OR (95% CI) | P | Cases (%) | OR (95% CI) | P | Cases (%) | OR (95% CI) | P | |||
| C1RL rs3813729 | CC | 375 80) | 362 (87) | 1.0 (ref) | 123 (91) | 1.0 (ref) | 83 (84) | 1.0 (ref) | |||
| CT | 94 (20) | 56 (13) | 0.60 (0.42–0.87) | 0.0062 | 12 (9) | 0.39 (0.20–0.73) | 0.0034 | 16 (16) | 0.71 (0.40–1.28) | 0.26 | |
| TT | 0 | 0 | — | — | 0 | — | — | 0 | — | — | |
| CT or TT | 94 (20) | 56 (13) | 0.60 (0.42–0.87) | 0.0062 | 12 (9) | 0.39 (0.20–0.73) | 0.0034 | 16 (16) | 0.71 (0.40–1.28) | 0.26 | |
| Trend | 469 | 418 | 0.60 (0.42–0.87) | 0.0062 | 135 | 0.39 (0.20–0.73) | 0.0034 | 99 | 0.71 (0.40–1.28) | 0.26 | |
| C1QG rs12756603 | AA | 350 (73) | 302 (71) | 1.0 (ref) | 92 (67) | 1.0 (ref) | 75 (74) | 1.0 (ref) | |||
| AG | 120 (25) | 110 (26) | 1.06 (0.78–1.43) | 0.72 | 42 (31) | 1.30 (0.85–1.98) | 0.23 | 22 (22) | 0.84 (0.50–1.41) | 0.51 | |
| GG | 12 (2) | 11 (3) | 1.01 (0.44–2.34) | 0.98 | 3 (2) | 1.03 (0.28–3.75) | 0.96 | 4 (4) | 1.36 (0.42–4.39) | 0.61 | |
| AG or GG | 132 (27) | 121 (29) | 1.05 (0.79–1.41) | 0.74 | 45 (33) | 1.27 (0.84–1.92) | 0.25 | 26 (26) | 0.89 (0.54–1.46) | 0.64 | |
| Trend | 482 | 423 | 1.04 (0.80–1.34) | 0.77 | 137 | 1.20 (0.84–1.73) | 0.32 | 101 | 0.96 (0.63–1.45) | 0.83 | |
| C2 rs497309 | AA | 405 (84) | 341 (80) | 1.0 (ref) | 106 (77) | 1.0 (ref) | 87 (86) | 1.0 (ref) | |||
| AC | 75 (16) | 80 (19) | 1.29 (0.91–1.83) | 0.15 | 30 (22) | 1.55 (0.96–2.50) | 0.07 | 13 (13) | 0.86 (0.45–1.63) | 0.64 | |
| CC | 2 (0.4) | 3 (0.7) | 1.58 (0.26–9.55) | 0.62 | 1 (0.7) | 1.68 (0.15–18.86) | 0.68 | 1 (0.99) | 1.89 (0.17–21.17) | 0.61 | |
| AC or CC | 77 (16) | 83 (20) | 1.30 (0.92–1.83) | 0.13 | 31 (23) | 1.56 (0.97–2.49) | 0.07 | 14 (14) | 0.89 (0.48–1.66) | 0.72 | |
| Trend | 482 | 424 | 1.29 (0.93–1.79) | 0.13 | 137 | 1.52 (0.97–2.37) | 0.07 | 101 | 0.94 (0.52–1.67) | 0.82 | |
| C3 rs344550 | GG | 198 (41) | 170 (40) | 1.0 (ref) | 49 (36) | 1.0 (ref) | 49 (49) | 1.0 (ref) | |||
| CG | 220 (46) | 190 (45) | 1.00 (0.75–1.33) | 0.99 | 65 (47) | 1.18 (0.78–1.80) | 0.43 | 41 (41) | 0.74 (0.46–1.17) | 0.20 | |
| CC | 64 (13) | 62 (15) | 1.15 (0.77–1.73) | 0.50 | 23 (17) | 1.44 (0.81–2.57) | 0.21 | 11 (11) | 0.72 (0.35–1.47) | 0.37 | |
| CG or CC | 284 (59) | 252 (60) | 1.03 (0.79–1.35) | 0.81 | 88 (64) | 1.24 (0.84–1.84) | 0.29 | 52 (51) | 0.73 (0.47–1.13) | 0.16 | |
| Trend | 482 | 422 | 1.05 (0.87–1.27) | 0.59 | 137 | 1.20 (0.91–1.58) | 0.20 | 101 | 0.81 (0.58–1.12) | 0.20 | |