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. Author manuscript; available in PMC: 2012 Jul 8.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2011 Oct 18;8(12):686–700. doi: 10.1038/nrgastro.2011.173

Figure 2.

Figure 2

Common methylated genes (and loci) identified at the histologic steps of the colorectal cancer polyp-adenoma-carcinoma sequence. Specific gene and loci hypermethylation has been observed in the different steps of the adenoma-cancer progression sequence implicating these genes in either the initiation of progression of colorectal cancer. The genes listed between normal epithelium and aberrant crypt focus as well as those genes listed between aberrant crypt focus and polyp/adenoma may be involved in the initiation of colorectal cancer. Those genes listed between polyp/adenoma and adenocarcinoma may play a role in the progression and metastasis of colorectal cancer. Note that we have only included genes (and loci) that have consistently been found to be hypermethylated at specific points in the progression sequence. *MINT1 and MINT31 are not genes; rather they are loci that have been found to be “methylated in tumor,” (aka MINT).