Table 1.
Epitope-specific CD8 T-cell lines used in the in vitro suppression assay.
| Patient ID |
Line# | HLA Restriction- Epitopea |
Proteinb | AA Sequence |
|---|---|---|---|---|
| P4470 | P1 | B07-HA9 | Gag p24 (84–92) | HPVHAGPIA |
| P2 | B07-RL9 | Nef (77–85) | RPMTYKAAL | |
| P5766 | P3 | A02-FK10 | p2p7p1p6 (70–79) | FLGKIWPSYK |
| P4 | B51-TI8 | RT (128–135) | TAFTIPSI | |
| P5 | B35-TY9 | RT (107–115) | TVLDVGDAY | |
| P1918 | P6 | A03-RK9 | Gag p17 (20–28) | RLRPGGKKK |
| P2824 | P7 | B57-IW9 | Gag p24 (15–23) | ISPRTLNAW |
| P8 | B57-KF11 | Gag p24 (30–40) | KAFSPEVIPMF | |
| P2883 | P9 | B53-EW10 | Gag p24 (71–80) | ETINEEAAEW |
| C6602 | C1 | B58-TF11 | Gag p24 (108–118) | TSTLQEQIGWF |
| C5168 | C2 | B27-KK10 | Gag p24 (131–140) | KRWIILGLNK |
| C2795 | C3 | B57-KF11 | Gag p24 (30–40) | KAFSPEVIPMF |
| C4 | B57-QW9 | Gag p24 (176–184) | QASQEVKNW | |
| C1655 | C5 | B57-KF11 | Gag p24 (30–40) | KAFSPEVIPMF |
| C6 | B57-TF11 | Gag p24 (108–118) | TSTLQEQIGWF | |
a
Underlined epitopes represent those restricted by HLA class I alleles associated with delayed disease progression.
b
Numbers in parentheses indicate epitope alignment to the HIV-1HXB2 reference strain.