. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Int Psychogeriatr. 2012 Mar 16;24(7):1065–1075. doi: 10.1017/S1041610212000191

Table 1. MRI Measurements as a Function of Study Group.

	Normal (n=29)		All MCI (n=20)		Statistic⁺	P value⁺	Effect size (Hedges'g)	Amnestic MCI (n=14)		Statistic⁺	P value⁺	Effect size (Hedges'g)

	Mean	SD	Mean	SD				Mean	SD
Semi Automated Volumetric (SVA) measures ^†
Grey Matter	37.213	0.753	37.033	1.038	0.7	0.487	-0.20	37.151	0.994	0.2	0.823	-0.07
White Matter	26.544	0.604	26.358	0.689	1.0	0.321	-0.29	26.401	0.783	0.7	0.512	-0.20
CSF	21.497	0.607	21.719	0.722	-1.2	0.250	0.33	21.864	0.787	-1.7	0.100	0.51
Hippocampus Right	0.217	0.025	0.201	0.034	390.0	0.031^*	-0.55	0.193	0.020	194.0	0.005^*	-0.97
Hippocampus Left	0.204	0.026	0.185	0.032	394.0	0.037^*	-0.68	0.176	0.027	203.0	0.010^*	-0.99
Hippocampus Both	0.421	0.049	0.385	0.059	372.0	0.013^*	-0.66	0.369	0.036	176.0	0.001^*	-1.08
Duara atrophy ratings
Cortical Atrophy	1.672	0.685	2.100	0.788	584.0	0.074	0.58	2.214	0.802	383.5	0.043^*	0.70
Lat. Ventricle, Rt.	1.414	0.825	1.900	0.852	588.5	0.063	0.57	2.000	0.961	380.5	0.056	0.63
Lat. Ventricle, Lft.	1.638	0.766	2.050	0.759	593.5	0.048^*	0.53	2.143	0.864	384.0	0.044^*	0.59
3^rd Ventricle	1.241	0.830	1.800	0.894	601.0	0.035^*	0.64	2.000	0.877	402.5	0.014^*	0.84
PWMH¹	1.517	0.829	1.950	0.887	579.0	0.097	0.50	2.000	0.784	369.0	0.102	0.56
SWMH²	1.379	0.942	1.650	0.933	544.5	0.341	0.28	1.857	0.864	362.5	0.140	0.49
Hippocampus, Rt.	1.379	0.820	2.100	1.119	603.5	0.033^*	0.74	2.286	1.204	399.5	0.018^*	0.89
Hippocampus, Lft.	1.586	1.053	2.100	1.119	573.0	0.133	0.47	2.500	1.019	401.0	0.017^*	0.82
Entorhinal Cortex, Rt.	1.138	1.217	1.950	1.099	611.5	0.024^*	0.68	2.214	0.975	410.0	0.010^*	0.88
Entorhinal Cortex, Lft.	1.379	1.237	2.150	1.137	606.5	0.030^*	0.63	2.500	0.941	415.5	0.006^*	0.91
Parahippocampal	0.931	1.163	1.450	1.099	572.0	0.127	0.45	1.643	1.082	377.0	0.066	0.59
Gyrus, Lft.
Parahippocampal	1.034	1.239	1.750	1.251	592.0	0.056	0.57	2.000	1.177	395.0	0.024^*	0.74
Gyrus, Lft.
Medial Temporal	1.149	0.941	1.835	1.012	612.0	0.027^*	0.69	2.049	1.003	409.5	0.012^*	0.88
Atrophy, Lt.
Medial Temporal	1.334	1.084	2.001	1.014	602.5	0.042^*	0.62	2.334	0.887	412.5	0.010^*	0.91
Atrophy, Lt.

⁺

appropriately tested by the t test or Wilcoxon Two-Sample Test

p<.05

^†

Expressed as a percentage of intra-cranial volume

Periventricular White Matter Hyperintestine

Subcortical White Matter Abnormalities