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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Biol Psychiatry. 2012 Jan 3;72(1):57–64. doi: 10.1016/j.biopsych.2011.11.022

Figure 2.

Figure 2

Using whole-brain voxel-based morphometry, more frequent recent life events and more traumatic life events were associated with lower mean gray matter volume (GMV) after controlling for age, sex, and total intracranial volume. Regions of interest are displayed (top row: x = 43.5; y = 13.5, z = −6; bottom row: x = 4.0, y = 47.0, z = 3.0) with recent life events regions in red, traumatic life events regions in yellow, and overlapping regions indicated in orange. Recent life events are associated with a region of the medial prefrontal cortex (7131 voxels; familywise error [FWE] p = .001) and the right insula (3893 voxels; FWE p = .028). R2 for the recent life events prefrontal region regression line = .13 and for the insula region = .13. Traumatic life events are associated with a region (12,835 voxels; FWE p <.001) of the medial prefrontal cortex, anterior cingulate, and subgenual areas. R2 for the traumatic life events regression line = .15. ROI, region of interest identified in the whole-brain voxel-based morphometry.