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Cav1.3 and calmodulin interaction. Calmodulin binds to Cav1.3 without calcium as apoCaM at the IQ motif. Calmodulin binds to calcium through its N-terminal and C-terminal loop and mediates calcium dependent inhibition (CDI). Editing modifies IQ to MR and inhibits calmodulin binding. Intracellular calcium increases in the absence of CDI.
